IGF1 and IGFBP3 tagging polymorphisms are associated with circulating levels of IGF1, IGFBP3 and risk of breast cancer
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چکیده
منابع مشابه
IGF1 and IGFBP3 polymorphisms and plasma levels in women.
To the Editor: D'Aloisio et al. report on IGF1 and IGFBP3 polymorphisms in relation to circulating insulinlike growth factor I (IGF-I) and insulin like growth factor binding protein-3 (IGFBP-3) plasma levels among African American and Caucasian women (CEBP 2009;18:954–66). In their study, mean IGF-I levels among Caucasian and African American were comparable. This is surprising because the Cauc...
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INTRODUCTION Insulin, insulin-like growth factor (IGF), and IGF binding protein (IGFBP) are involved in cell growth and proliferation and are thought to be important in the etiology of colorectal cancer. We hypothesize that genetic polymorphisms of insulin receptor substrates (IRS-1 and IRS-2), IGF-I, and IGFBP-3 alter colorectal cancer risk because of their roles in the insulin-related signali...
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Insulin-like growth factor (IGF) 1 and its binding proteins foster cellular proliferation and inhibit apoptosis. In vitro studies show that IGF1 increases ovarian cell growth and invasive potential, suggesting a role for the IGF1 pathway in ovarian cancer etiology. We evaluated genetic variation in the IGF1, IGFBP1 and IGFBP3 genes in relation to ovarian cancer risk by genotyping 29 haplotype-t...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2005
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddi398